About Regelle

/About Regelle
About Regelle2018-06-11T12:22:40+00:00

Regelle is vaginal moisturiser, clinically proven to provide immediate relief from dryness and discomfort.

Non Hormonal: Regelle is a non-hormonal long lasting vaginal moisturiser.

Long Lasting: It is the perfect choice for women seeking a long-lasting non-hormonal solution to vaginal dryness. Regelle provides continuous moisturisation for up to 3 days after each application, unlike short acting lubricants.

Immediate Relief: Regelle provides immediate comfort and long-lasting relief from symptoms of vaginal dryness.

Rejuvenates: Regelle also improves the elasticity of the vaginal wall, encourages the return of natural secretions and restores the natural pH of the vagina.

Easy to Use: Each box of Regelle contains either 3, 6 or 12 individual Applicators .The applicator is simply inserted into the vagina, squeezed, then removed and discarded. The single use applicator delivers moisture where it is needed.

Can be use with HRT: Regelle is also suitable for use by patients taking systemic Hormone Replacement Therapy (HRT).

Hygienic: Regelle is prefilled into single-use applicators, this hygienic solution allows you to use the applicator once and discard.

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How Regelle works:

1.
Regelle® coats vaginal tissues to provide instant relief to dry cells.

2.
Regelle® delivers continuous moisture, which the cells absorb, causing them to regain their natural structure and elasticity.

3.
Dead skin cells are naturally shed leaving the vagina both moisturised and rejuvenated.

Review Regelle
For millions of women, vaginal dryness is a real problem that affects and interferes with their day-to-day lives. Women may experience dryness during the menopause, times of stress or as a side effect of certain medications and medical treatments. The effects of vaginal dryness vary from woman to woman, ranging from minor discomfort to painful sexual intercourse. Regardless of the level of discomfort, vaginal dryness can impact your daily life.

A recent survey of 500 women in Ireland reported 7 out of 10 experience the painful debilitating effects of vaginal dryness at some stage. However, 59% of sufferers do not seek help from their GP or healthcare professional. Almost 20%, quoted embarrassment as a factor in not seeking help, and a further 13% assumed their condition would go away.

23% of sufferers said this common condition affects their confidence, while, for 41% of women, vaginal dryness causes painful sex, and 45% said they avoid sex altogether. 

Physical symptoms of vaginal dryness include itching, pain and discomfort, while 36% of women in the survey said that vaginal dryness even made exercising uncomfortable.

Regelle, Long lasting vaginal moisturiser is clinically proven to provide immediate relief from the discomfort associated with vaginal dryness. Unlike short acting lubricants, Regelle soothes by coating the entire vaginal passage resulting in immediate relief with each application lasting up to three days.

*Opinions.ie (2017) Vaginal Dryness survey.

Regelle® works by lining the inside of the vagina, providing moisturisation, lubrication and comfort1.

The polycarbophil-carbopol based vaginal gel has a high level of bio-adhesiveness capable of ensuring a prolonged moisturising action on the epithelium of the vaginal mucous membrane2. This gel is capable of adhering to the vaginal mucous membranes thanks to the presence of two characteristic polyacid polymers having a high molecular weight and a molecular structure very similar to that of the vaginal mucous: Polycarbophil and carbopol2. Polycarbophil is hydrophilic and provides direct cellular ‘moisturising’ action resulting from an increased flow of water molecules from outside to the inside of the cells on the surface of vaginal mucous membrane. This action creates a moist film over the vaginal wall hydrating the underlying mucosa3. This movement of water into the cells of the vaginal epithelium is promoted by the particular unique structure of the polymers in this gel2. Being bio-adhesive, Regelle has been shown in laboratory and clinical studies to adhere to tissue for 24-72h, resulting in diffusion of water from the gel to the underlying vaginal mucosa3.

Furthermore, polycarbophil and carbopol are substances with a buffering action and their use in women experiencing menopause either naturally or as a result of surgery has led to a correction of the vaginal pH values comparable to those obtained with hormone replacement therapy4.

The pH of the polycarbophil gel is 3.0 and it buffers to a normal vaginal pH of 3.5 to 5.03.

Regelle® is so safe patients can use it confidently for years, even decades, and with regular use some women may find that fewer applications are needed, because the dryness reduces.

Step 1
Regelle® coats vaginal tissues to provide instant relief to dry cells. 

Step 2
Regelle® delivers continuous moisture, which the cells absorb, causing them to regain their natural structure and elasticity.

Step 3
Dead skin cells are naturally shed leaving the vagina both moisturised and rejuvenated.


References:
  1. Kora Healthcare Regelle Product Data Sheet
  2. Garg et al (2001) Properties of new acid buffering bioadhesive vaginal formulation. Contraception 64. 67-75.
  3. Gelfand, M et al (1994) Treating Vaginal Dryness in Brest Cancer Patients: Results of Applying a Polycarbophil Moisturizing Gel. Journal of Women’s Health; volume 3, Number 6, p427-433#
  4. Bachmann, G.A et al (1992) Long Term Nonhormonal Treatment of Vaginal Dryness. Clinical Practice in Sexuality; Volume 8, Number 8/9, p 3-8>

Regelle is available in 3 pack sizes containing either 3, 6 or 12 single-use hygienic applicators.

Regelle is available in all leading pharmacies and can be purchased online.

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All online purchases can be sent to a delivery address of choice and is shipped in discreet packaging.

If you have used or are currently using Regelle and would like to offer some feedback on your user experience, please do so by completing the questionnaire.

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If you have any further comments or feedback on your user experience, please email info@regelle.ie

For millions of women, vaginal dryness is a real problem that affects and interferes with their day-to-day lives. Women may experience dryness during the menopause, times of stress or as a side effect of certain medications and medical treatments. The effects of vaginal dryness vary from woman to woman, ranging from minor discomfort to painful sexual intercourse. Regardless of the level of discomfort, vaginal dryness can impact your daily life.

A recent survey of 500 women in Ireland reported 7 out of 10 experience the painful debilitating effects of vaginal dryness at some stage. However, 59% of sufferers do not seek help from their GP or healthcare professional. Almost 20%, quoted embarrassment as a factor in not seeking help, and a further 13% assumed their condition would go away.

Out of the women who did seek help, the GP was their main point of contact, with 75% of women consulting GPs about their vaginal dryness.

23% of sufferers said this common condition affects their confidence, while, for 41% of women, vaginal dryness causes painful sex, and 45% said they avoid sex altogether.

Physical symptoms of vaginal dryness include itching, pain and discomfort, while 36% of women in the survey said that vaginal dryness even made exercising uncomfortable.

Regelle, Long lasting vaginal moisturiser is clinically proven to provide immediate relief from the discomfort associated with vaginal dryness. Unlike short acting lubricants, Regelle soothes by coating the entire vaginal passage resulting in immediate relief with each application lasting up to three days.

*Opinions.ie (2017) Vaginal Dryness survey.

Sexuality doesn’t stop with age

Due to a lengthening of the average lifespan and longer life expectancy after menopause, vaginal atrophy is destined to become a clinical problem with an increasingly greater epidemiological significance. The seriousness of this menopausal symptom should not be minimized, as vaginal dryness represents an uncomfortable problem, with physical and psychological consequences that can have a deleterious impact on the patient’s quality of life.

It is estimated that up to 40% of your post-menopausal patients may need your advice but are simply too embarrassed to ask. Furthermore, even if you are prescribing HRT to your patients, it is shown that 25% of menopausal women who take hormone replacement therapy continue to present with the signs and symptoms of vaginal atrophy.1

Vaginal atrophy is still very much a taboo subject as many of your patients may too embarrassed to talk to their partners, friends and even doctors about their problems. Due to embarrassment or perceived taboo, patients are reluctant to seek out professional advice and treatment which can have a major impact on your patients everyday vaginal comfort, self-confidence, sex life and ultimately quality of life. As a health professional, you can help your patients by encouraging your post-menopausal patients to talk openly about their health issues such as vaginal dryness so that you have the opportunity to provide support, advice and treatment information.

Sadly, many women undergoing treatment for cancer do not even mention the discomfort of their vaginal dryness to their doctor for fear of sounding trivial and some will shy away from sex, which can leave their partner feeling rejected and in turn lead to more complicated relationship issues at an already difficult time.

Reference
  1. Sturdee DW and Panay N (2010) Recommendations for the management of post-menopausal vaginal atrophy. Climacteric; 13:509-522.
Regelle works by lining the inside of the vagina, providing moisturisation, lubrication and comfort1.


The polycarbophil-carbopol based vaginal gel has a high level of bio-adhesiveness capable of ensuring a prolonged moisturising action on the epithelium of the vaginal mucous membrane2. This gel is capable of adhering to the vaginal mucous membranes thanks to the presence of two characteristic polyacid polymers having a high molecular weight and a molecular structure very similar to that of the vaginal mucous: Polycarbophil and carbopol2. Polycarbophil is hydrophilic and provides direct cellular ‘moisturising’ action resulting from an increased flow of water molecules from outside to the inside of the cells on the surface of vaginal mucous membrane. This action creates a moist film over the vaginal wall hydrating the underlying mucosa3. This movement of water into the cells of the vaginal epithelium is promoted by the particular unique structure of the polymers in this gel2. Being bio-adhesive, Regelle has been shown in laboratory and clinical studies to adhere to tissue for 24-72h, resulting in diffusion of water from the gel to the underlying vaginal mucosa3.


Furthermore, polycarbophil and carbopol are substances with a buffering action and their use in women experiencing menopause either naturally or as a result of surgery has led to a correction of the vaginal pH values comparable to those obtained with hormone replacement therapy4.


The pH of the polycarbophil gel is 3.0 and it buffers to a normal vaginal pH of 3.5 to 5.03.

Regelle® is so safe patients can use it confidently for years, even decades, and with regular use some women may find that fewer applications are needed, because the dryness reduces. 

Step 1
Regelle® coats vaginal tissues to provide instant relief to dry cells. 

Step 2
Regelle® delivers continuous moisture, which the cells absorb, causing them to regain their natural structure and elasticity.

Step 3
Dead skin cells are naturally shed leaving the vagina both moisturised and rejuvenated. References:
  1. Kora Healthcare Regelle Product Data Sheet
  2. Garg et al (2001) Properties of new acid buffering bioadhesive vaginal formulation. Contraception 64. 67-75.
  3. Gelfand, M et al (1994) Treating Vaginal Dryness in Brest Cancer Patients: Results of Applying a Polycarbophil Moisturizing Gel. Journal of Women’s Health; volume 3, Number 6, p427-433#
  4. Bachmann, G.A et al (1992) Long Term Nonhormonal Treatment of Vaginal Dryness. Clinical Practice in Sexuality; Volume 8, Number 8/9, p 3-8
Regelle® is a long lasting vaginal moisturiser intended for the symptomatic relief of vaginal atrophy, dryness, itching, irritation and discomfort. 

The recommended Regelle® dosage is as follows:

One application (2.5 g) to be inserted into the vagina every three days, preferably in the morning. 

Maintenance therapy can be achieved with a three times weekly application. Depending on the level of dryness, Regelle® can be used more or less frequently and can be used daily. 

Regelle comes in a pack of 3, 6 or 12 single-use applicators.

Step 1: Grip the applicator by the thick end. Shake down the contents to ensure they’re at the thin end of the applicator.

Step 2:Twist off the tab and discard.

Step 3: The applicator can be inserted into the vagina while you are lying down on your back with your knees bent, or in a sitting position. Gently insert the thin end into the vagina as far as it will go comfortably.

Step 4: Squeeze the thick end of the applicator firmly to deposit the gel. Remove the applicator and discard appropriately.

There is a wide body of clinical evidence supporting the use of Regelle®. Please see below links to clinical papers looking at the use of polycarbophil gels for the symptomatic relief of vaginal atrophy, dryness, itching, irritation and discomfort. 

Clinical Paper 1:
In a study by Gelfand et al (1994) treating vaginal dryness in breast Cancer Patients Polycarbophil Moisturising gel show that a polycarbophil vaginal moisturiser gel effectively relieves vaginal dryness in most patients without causing significant side effects. This study also showed a statistically significant reduction in mean vaginal pH and improvement in overall vaginal elasticity scores, as well as significant improvement in vaginal health measures at each monthly interval. 

Gelfand, M et al (1994) Treating Vaginal Dryness in Brest Cancer Patients: Results of Applying a Polycarbophil Moisturizing Gel. Journal of Women’s Health; volume 3, Number 6, p427-433

Clinical Paper 2:
In a comparative study by Nachtigall et al (1994) of a polycarbophil gel versus local oestrogen in menopausal women, a statistically significant return of vaginal moisture and vaginal fluid volume was shown by week 4 in both groups. Vaginal elasticity also increased in both groups. No serious side effects were reported. The result indicated that the bioadhesive vaginal moisturiser was a safe and effective alternative to oestrogen vaginal creams, with both therapies exhibiting statistically significant increases in vaginal moisture, vaginal fluid, and vaginal elasticity with a return of the premenopausal pH state. 

Nachtigall, L.E (1994) Comparative study: Replens versus local estrogen in menopausal women. Fertility and Sterility.Volume 61, Number 1, p 178-180.

Clinical Paper 3:
In a 12 month study by Bachmann et al of peri-menopausal and post-menopausal women, use of polycarbophil gel 3 times per week for one year showed that not only had vaginal health improved but this improvement was maintained as long as subjects were using the vaginal product. All parameter of the vaginal health index showed improvement including vaginal moisture, vaginal fluid volume, vaginal pH, vaginal epithelial integrity and vaginal elasticity. Overall the gel was found be well tolerated and effective in improving overall vaginal health for one year of continuous use. There were no patients who dropped out due to adverse events.

Bachmann, G.A et al (1992) Long Term Nonhormonal Treatment of Vaginal Dryness. Clinical Practice in Sexuality; Volume 8, Number 8/9, p 3-8

Clinical Paper 4:
In the VALYD study by Mincigrucci et al (2005), the use of a polycarbophil gel, either alone or in combination with HRT, brought about a significant and clinically relevant improvement in the Vaginal Health Index Score and symptoms related to vaginal atrophy. In particular, significant reductions of itching, burning and vaginal discharges were observed Dyspareunia dropped by 84%: this reduction occurred both in women taking a hormonal therapy in conjunction with a non-hormonal vaginal therapy and among women receiving only non-hormonal vaginal therapy.

Mincigrucci M et al (2005) Results of the VALYD study: A multicenter, epidemiological, observational, prospective study of vaginal atrophy and quality of life in menopausal women. Volume XX, No. 2, p 2-6.
Regelle® is available in 3 pack sizes containing either 3, 6 or 12 single-use hygienic applicators.

Regelle is available in all leading pharmacies and can be purchased online.

Buy Now


All online purchases can be sent to a delivery address of choice and is shipped in discreet packaging.

FAQ’s

What makes Regelle different to a lubricant?

Lubricants can provide temporary relief and help reduce friction during intercourse. However, Regelle is the perfect choice for women seeking a long-lasting, solution to vaginal dryness. Regelle provides continuous moisturisation for up to three days unlike short acting lubricants. Regelle contains 78.82% purified water.

Is Regelle suitable for patients taking systemic Hormone Replacement Therapy (HRT)?

Yes, Regelle is suitable for use by patients taking systemic HRT.

Can condoms be used while using Regelle?

Yes. Regelle is a water based moisturiser that does not interfere with latex.

How is Regelle administered?

Regelle comes in pre-filled hygienic single use applicators. The applicator is simply inserted into the vagina, squeezed, then removed and discarded. The single use applicator delivers moisture where it is needed.

What other tips will help with Vaginal Dryness?

Wear breathable cotton underwear and loose clothing until symptoms improve. Do not use soaps, shower gels, bath oils or disinfectants to cleanse the vaginal area. Use Regelle for long lasting immediate relief.

Are there any side effects while using Regelle?

You may notice a residue or discharge from the time you begin using Regelle. This happens when dead skin cells are secreted, especially if you have been dry for some time. Although your body naturally sheds dry vaginal skin cells, Regelle enhances this renewal process by flushing them away and leaving behind softer and more supple tissue. Regular use of Regelle helps to prevent the build up of dry vaginal tissue and the discharge should dissipate.

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